Assay Detail
Functional
CHEMBL5385083
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of 6-OAU induced calcium response incubated for 10 mins by calcium mobilization assay
44
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Unsymmetrical Phosphodiesters as GPR84 Antagonists with High Blood Exposure for the Treatment of Lung Inflammation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 6.34 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5413740 | — | — | 1 | 7.92 |
| CHEMBL5411648 | — | — | 1 | 7.82 |
| CHEMBL5433078 | — | — | 1 | 7.64 |
| CHEMBL5395660 | — | — | 2 | 7.60 |
| CHEMBL5428552 | — | — | 1 | 7.39 |
| CHEMBL5416118 | — | — | 1 | 7.21 |
| CHEMBL5400040 | — | — | 1 | 7.17 |
| CHEMBL5194984 | — | — | 1 | 7.13 |
| CHEMBL5407283 | — | — | 1 | 7.04 |
| CHEMBL5429540 | — | — | 1 | 6.97 |
| CHEMBL5394910 | — | — | 1 | 6.96 |
| CHEMBL5423643 | — | — | 1 | 6.90 |
| CHEMBL5417993 | — | — | 1 | 6.89 |
| CHEMBL5434490 | — | — | 1 | 6.78 |
| CHEMBL5396626 | — | — | 1 | 6.71 |
| CHEMBL5421575 | — | — | 1 | 6.71 |
| CHEMBL5420273 | — | — | 1 | 6.66 |
| CHEMBL5395766 | — | — | 1 | 6.62 |
| CHEMBL5407593 | — | — | 1 | 6.49 |
| CHEMBL5431524 | — | — | 1 | 6.47 |
| CHEMBL5425683 | — | — | 1 | 6.40 |
| CHEMBL5433203 | — | — | 1 | 6.39 |
| CHEMBL5402662 | — | — | 1 | 6.35 |
| CHEMBL5439033 | — | — | 1 | 6.29 |
| CHEMBL5412502 | — | — | 1 | 6.26 |
| CHEMBL5404018 | — | — | 1 | 6.26 |
| CHEMBL5418028 | — | — | 1 | 6.21 |
| CHEMBL5400422 | — | — | 1 | 6.18 |
| CHEMBL5413350 | — | — | 1 | 6.15 |
| CHEMBL5404966 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5413740 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5411648 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5433078 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL5395660 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5428552 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL5416118 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL5400040 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL5395660 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL5194984 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL5407283 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL5429540 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL5394910 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5423643 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL5417993 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5434490 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL5421575 | — | IC50 | = | 196.0 | nM | 6.71 |
| CHEMBL5396626 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL5420273 | — | IC50 | = | 219.0 | nM | 6.66 |
| CHEMBL5395766 | — | IC50 | = | 238.0 | nM | 6.62 |
| CHEMBL5407593 | — | IC50 | = | 325.0 | nM | 6.49 |
| CHEMBL5431524 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL5425683 | — | IC50 | = | 396.0 | nM | 6.40 |
| CHEMBL5433203 | — | IC50 | = | 405.0 | nM | 6.39 |
| CHEMBL5402662 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL5439033 | — | IC50 | = | 517.0 | nM | 6.29 |
| CHEMBL5412502 | — | IC50 | = | 554.0 | nM | 6.26 |
| CHEMBL5404018 | — | IC50 | = | 547.0 | nM | 6.26 |
| CHEMBL5418028 | — | IC50 | = | 609.0 | nM | 6.21 |
| CHEMBL5400422 | — | IC50 | = | 658.0 | nM | 6.18 |
| CHEMBL5413350 | — | IC50 | = | 711.0 | nM | 6.15 |
| CHEMBL5404966 | — | IC50 | = | 817.0 | nM | 6.09 |
| CHEMBL5409696 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL5394273 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL5394851 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL5437225 | — | IC50 | = | 2830.0 | nM | 5.55 |
| CHEMBL5415068 | — | IC50 | = | 2980.0 | nM | 5.53 |
| CHEMBL5414181 | — | IC50 | = | 3840.0 | nM | 5.42 |
| CHEMBL5423506 | — | IC50 | = | 4010.0 | nM | 5.40 |
| CHEMBL5404335 | — | IC50 | = | 3990.0 | nM | 5.40 |
| CHEMBL5395990 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL5418832 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL5433983 | — | IC50 | = | 21800.0 | nM | 4.66 |
| CHEMBL5425199 | — | IC50 | = | 29600.0 | nM | 4.53 |
| CHEMBL5434645 | — | IC50 | = | 39500.0 | nM | 4.40 |