Assay Detail
Functional
CHEMBL5385186
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Antiproliferative activity against human HL-60 cells incubated for 72 hrs by CCK-8 assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Exploration of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Bispecific Inhibitors Based on the Moiety of Fedratinib for Treatment of Both Hematologic Malignancies and Solid Cancers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.35 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.30 |
| CHEMBL5433552 | — | — | 1 | 5.59 |
| CHEMBL5427399 | — | — | 1 | 5.59 |
| CHEMBL5395502 | — | — | 1 | 5.47 |
| CHEMBL5437969 | — | — | 1 | 5.36 |
| CHEMBL1287853 | FEDRATINIB | 4.0 | 1 | 5.33 |
| CHEMBL5427372 | — | — | 1 | 5.31 |
| CHEMBL5403924 | — | — | 1 | 5.19 |
| CHEMBL5440597 | — | — | 1 | 5.17 |
| CHEMBL5418300 | — | — | 1 | 5.16 |
| CHEMBL5432341 | — | — | 1 | 5.15 |
| CHEMBL5424724 | — | — | 1 | 4.96 |
| CHEMBL5409823 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5433552 | — | IC50 | = | 2580.0 | nM | 5.59 |
| CHEMBL5427399 | — | IC50 | = | 2580.0 | nM | 5.59 |
| CHEMBL5395502 | — | IC50 | = | 3370.0 | nM | 5.47 |
| CHEMBL5437969 | — | IC50 | = | 4410.0 | nM | 5.36 |
| CHEMBL1287853 | FEDRATINIB | IC50 | = | 4660.0 | nM | 5.33 |
| CHEMBL5427372 | — | IC50 | = | 4910.0 | nM | 5.31 |
| CHEMBL5403924 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL5440597 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL5418300 | — | IC50 | = | 6850.0 | nM | 5.16 |
| CHEMBL5432341 | — | IC50 | = | 7130.0 | nM | 5.15 |
| CHEMBL5424724 | — | IC50 | = | 11090.0 | nM | 4.96 |
| CHEMBL5409823 | — | IC50 | = | 12030.0 | nM | 4.92 |