Assay Detail
Binding
CHEMBL5385367
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NIK (unknown origin) catalyzed ATP hydrolysis assessed as inhibition constant by fluorescence polarization method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mitogen-activated protein kinase kinase kinase 14 (CHEMBL5888) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Filling a nick in NIK: Extending the half-life of a NIK inhibitor through structure-based drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 9.38 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4209095 | — | — | 1 | 9.70 |
| CHEMBL5405484 | — | — | 1 | 9.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4209095 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL5405484 | — | Ki | = | 0.88 | nM | 9.06 |