Assay Detail

CHEMBL5385981

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Binding

Inhibition of URAT1 (unknown origin)

ChEMBL ↗

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Target

Solute carrier family 22 member 12 (CHEMBL6120) ↗

Open DB target context

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Solute carrier family 22 member 12 (CHEMBL6120) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Solute carrier family 22 member 12

CHEMBL6120

Anchored from Assay target.

Protein identity Solute carrier family 22 member 12

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Solute carrier family 22 member 12 (CHEMBL6120) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Recent advances in gout drugs.

Shi C, Zhou Z, Chi X, Xiu S, Yi C, Jiang Z, Chen R, Zhang L, Liu Z.
Eur J Med Chem (2023) 245 : 114890 -114890
PubMed 36335742 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	5.14	5.14

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2105720	LESINURAD	4.0	1	5.14

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2105720	LESINURAD	IC50	=	7300.0	nM	5.14