Assay Detail
Binding
CHEMBL5386175
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human JNK3 incubated for 40 mins in presence of ATP and [gamma33P-ATP] by scintillation counting method
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel imidazole chemotypes as isoform-selective JNK3 inhibitors for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 6.85 | 10.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL210618 | — | — | 1 | 10.17 |
| CHEMBL5396715 | — | — | 1 | 9.00 |
| CHEMBL5418449 | — | — | 1 | 8.70 |
| CHEMBL5406554 | — | — | 1 | 8.52 |
| CHEMBL5405404 | — | — | 1 | 8.39 |
| CHEMBL5394033 | — | — | 1 | 8.30 |
| CHEMBL5436709 | — | — | 1 | 8.28 |
| CHEMBL5396572 | — | — | 1 | 8.21 |
| CHEMBL5419748 | — | — | 1 | 8.15 |
| CHEMBL5403895 | — | — | 1 | 8.10 |
| CHEMBL5408056 | — | — | 1 | 8.00 |
| CHEMBL5428554 | — | — | 1 | 7.62 |
| CHEMBL5439223 | — | — | 1 | 7.26 |
| CHEMBL5428367 | — | — | 1 | 6.85 |
| CHEMBL5400530 | — | — | 1 | 6.54 |
| CHEMBL5416746 | — | — | 1 | 6.49 |
| CHEMBL5429268 | — | — | 1 | 6.40 |
| CHEMBL5422393 | — | — | 1 | 6.38 |
| CHEMBL5432545 | — | — | 1 | 6.21 |
| CHEMBL5438738 | — | — | 1 | 6.09 |
| CHEMBL5396830 | — | — | 1 | 5.82 |
| CHEMBL5416681 | — | — | 1 | 5.48 |
| CHEMBL5425080 | — | — | 1 | 5.30 |
| CHEMBL5407999 | — | — | 1 | 5.20 |
| CHEMBL5405861 | — | — | 1 | 5.17 |
| CHEMBL5425582 | — | — | 1 | 5.07 |
| CHEMBL5409831 | — | — | 1 | 5.01 |
| CHEMBL5420481 | — | — | 1 | 5.00 |
| CHEMBL5397268 | — | — | 1 | 4.88 |
| CHEMBL5438946 | — | — | 1 | 4.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL210618 | — | IC50 | = | 0.068 | nM | 10.17 |
| CHEMBL5396715 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5418449 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5406554 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5405404 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL5394033 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5436709 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL5396572 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL5419748 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5403895 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5408056 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5428554 | — | IC50 | = | 24.1 | nM | 7.62 |
| CHEMBL5439223 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5428367 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL5400530 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL5416746 | — | IC50 | = | 321.0 | nM | 6.49 |
| CHEMBL5429268 | — | IC50 | = | 396.0 | nM | 6.40 |
| CHEMBL5422393 | — | IC50 | = | 421.0 | nM | 6.38 |
| CHEMBL5432545 | — | IC50 | = | 611.0 | nM | 6.21 |
| CHEMBL5438738 | — | IC50 | = | 814.0 | nM | 6.09 |
| CHEMBL5396830 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL5416681 | — | IC50 | = | 3280.0 | nM | 5.48 |
| CHEMBL5425080 | — | IC50 | = | 4960.0 | nM | 5.30 |
| CHEMBL5407999 | — | IC50 | = | 6270.0 | nM | 5.20 |
| CHEMBL5405861 | — | IC50 | = | 6760.0 | nM | 5.17 |
| CHEMBL5425582 | — | IC50 | = | 8560.0 | nM | 5.07 |
| CHEMBL5409831 | — | IC50 | = | 9840.0 | nM | 5.01 |
| CHEMBL5420481 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5397268 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL5438946 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL5422325 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5395134 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5402659 | — | IC50 | - | — | - | |
| CHEMBL5413091 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5434902 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5428703 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5439711 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5432802 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5437442 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5431761 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5410924 | — | IC50 | > | 10000.0 | nM | - |