Assay Detail
Binding
CHEMBL5386787
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of JNK3 (unknown origin) using ATF2 as substrate incubated for 40 mins in presence of [gamma33P]ATP by scintillation counting analysis
53
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel 1,4,5,6-tetrahydrocyclopenta[d]imidazole-5-carboxamide-based JNK3 inhibitors: Design, synthesis, molecular docking, and therapeutic potential in neurodegenerative diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 53 | 7.77 | 9.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5403678 | — | — | 1 | 9.42 |
| CHEMBL5423620 | — | — | 1 | 9.25 |
| CHEMBL5411160 | — | — | 1 | 9.22 |
| CHEMBL5398642 | — | — | 1 | 9.14 |
| CHEMBL5436023 | — | — | 1 | 9.14 |
| CHEMBL5401511 | — | — | 1 | 9.11 |
| CHEMBL5424946 | — | — | 1 | 8.97 |
| CHEMBL5429577 | — | — | 1 | 8.96 |
| CHEMBL5408675 | — | — | 1 | 8.92 |
| CHEMBL5431060 | — | — | 1 | 8.92 |
| CHEMBL5430858 | — | — | 1 | 8.76 |
| CHEMBL5399794 | — | — | 1 | 8.75 |
| CHEMBL5438506 | — | — | 1 | 8.36 |
| CHEMBL5424892 | — | — | 1 | 8.32 |
| CHEMBL5425334 | — | — | 1 | 8.19 |
| CHEMBL5405705 | — | — | 1 | 8.17 |
| CHEMBL5419594 | — | — | 1 | 8.05 |
| CHEMBL5435809 | — | — | 1 | 8.04 |
| CHEMBL5436510 | — | — | 1 | 8.03 |
| CHEMBL5401592 | — | — | 1 | 8.00 |
| CHEMBL5412347 | — | — | 1 | 7.99 |
| CHEMBL5413870 | — | — | 1 | 7.98 |
| CHEMBL5414227 | — | — | 1 | 7.98 |
| CHEMBL210618 | — | — | 1 | 7.85 |
| CHEMBL5436937 | — | — | 1 | 7.83 |
| CHEMBL5423677 | — | — | 1 | 7.81 |
| CHEMBL5420339 | — | — | 1 | 7.79 |
| CHEMBL5401605 | — | — | 1 | 7.67 |
| CHEMBL5403970 | — | — | 1 | 7.63 |
| CHEMBL5395372 | — | — | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5403678 | — | IC50 | = | 0.379 | nM | 9.42 |
| CHEMBL5423620 | — | IC50 | = | 0.564 | nM | 9.25 |
| CHEMBL5411160 | — | IC50 | = | 0.607 | nM | 9.22 |
| CHEMBL5398642 | — | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL5436023 | — | IC50 | = | 0.716 | nM | 9.14 |
| CHEMBL5401511 | — | IC50 | = | 0.779 | nM | 9.11 |
| CHEMBL5424946 | — | IC50 | = | 1.08 | nM | 8.97 |
| CHEMBL5429577 | — | IC50 | = | 1.11 | nM | 8.96 |
| CHEMBL5408675 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL5431060 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL5430858 | — | IC50 | = | 1.72 | nM | 8.76 |
| CHEMBL5399794 | — | IC50 | = | 1.76 | nM | 8.75 |
| CHEMBL5438506 | — | IC50 | = | 4.33 | nM | 8.36 |
| CHEMBL5424892 | — | IC50 | = | 4.83 | nM | 8.32 |
| CHEMBL5425334 | — | IC50 | = | 6.39 | nM | 8.19 |
| CHEMBL5405705 | — | IC50 | = | 6.82 | nM | 8.17 |
| CHEMBL5419594 | — | IC50 | = | 8.92 | nM | 8.05 |
| CHEMBL5435809 | — | IC50 | = | 9.06 | nM | 8.04 |
| CHEMBL5436510 | — | IC50 | = | 9.36 | nM | 8.03 |
| CHEMBL5401592 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5412347 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL5413870 | — | IC50 | = | 10.5 | nM | 7.98 |
| CHEMBL5414227 | — | IC50 | = | 10.4 | nM | 7.98 |
| CHEMBL210618 | — | IC50 | = | 14.15 | nM | 7.85 |
| CHEMBL5436937 | — | IC50 | = | 14.8 | nM | 7.83 |
| CHEMBL5423677 | — | IC50 | = | 15.4 | nM | 7.81 |
| CHEMBL5420339 | — | IC50 | = | 16.4 | nM | 7.79 |
| CHEMBL5401605 | — | IC50 | = | 21.5 | nM | 7.67 |
| CHEMBL5403970 | — | IC50 | = | 23.4 | nM | 7.63 |
| CHEMBL5395372 | — | IC50 | = | 24.9 | nM | 7.60 |
| CHEMBL5402048 | — | IC50 | = | 28.2 | nM | 7.55 |
| CHEMBL5433276 | — | IC50 | = | 30.6 | nM | 7.51 |
| CHEMBL5431146 | — | IC50 | = | 31.4 | nM | 7.50 |
| CHEMBL5427166 | — | IC50 | = | 36.1 | nM | 7.44 |
| CHEMBL5416188 | — | IC50 | = | 49.9 | nM | 7.30 |
| CHEMBL5436272 | — | IC50 | = | 52.8 | nM | 7.28 |
| CHEMBL5426262 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL5418507 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL5399618 | — | IC50 | = | 65.4 | nM | 7.18 |
| CHEMBL5424108 | — | IC50 | = | 87.3 | nM | 7.06 |
| CHEMBL5423313 | — | IC50 | = | 93.9 | nM | 7.03 |
| CHEMBL5422901 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL5403762 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL5407257 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL5428039 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL5406704 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5410846 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL5439571 | — | IC50 | = | 243.0 | nM | 6.61 |
| CHEMBL5425684 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5397833 | — | IC50 | = | 300.0 | nM | 6.52 |