Assay Detail
Binding
CHEMBL5386791
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of p38alpha (unknown origin) incubated for 20 mins in presence of 33P-ATP
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel 1,4,5,6-tetrahydrocyclopenta[d]imidazole-5-carboxamide-based JNK3 inhibitors: Design, synthesis, molecular docking, and therapeutic potential in neurodegenerative diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.87 | 7.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278041 | SB-202190 | — | 1 | 7.61 |
| CHEMBL5424946 | — | — | 1 | 7.43 |
| CHEMBL5411160 | — | — | 1 | 7.27 |
| CHEMBL5398642 | — | — | 1 | 7.15 |
| CHEMBL5401511 | — | — | 1 | 7.07 |
| CHEMBL5403678 | — | — | 1 | 6.67 |
| CHEMBL5429577 | — | — | 1 | 6.54 |
| CHEMBL5436023 | — | — | 1 | 6.54 |
| CHEMBL5408675 | — | — | 1 | 6.27 |
| CHEMBL5423620 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278041 | SB-202190 | IC50 | = | 24.6 | nM | 7.61 |
| CHEMBL5424946 | — | IC50 | = | 37.46 | nM | 7.43 |
| CHEMBL5411160 | — | IC50 | = | 53.25 | nM | 7.27 |
| CHEMBL5398642 | — | IC50 | = | 70.56 | nM | 7.15 |
| CHEMBL5401511 | — | IC50 | = | 84.7 | nM | 7.07 |
| CHEMBL5403678 | — | IC50 | = | 215.8 | nM | 6.67 |
| CHEMBL5429577 | — | IC50 | = | 285.3 | nM | 6.54 |
| CHEMBL5436023 | — | IC50 | = | 291.5 | nM | 6.54 |
| CHEMBL5408675 | — | IC50 | = | 531.7 | nM | 6.27 |
| CHEMBL5423620 | — | IC50 | = | 751.5 | nM | 6.12 |