Assay Detail
Binding
CHEMBL5387594
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Modulation of S1PR1 (unknown origin)
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
S1PR1 modulators in multiple sclerosis: Efficacy, safety, comparison, and chemical structure insights.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 8.09 | 10.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4093489 | — | — | 1 | 10.56 |
| CHEMBL3707375 | AMISELIMOD | 2.0 | 1 | 10.10 |
| CHEMBL3899384 | — | — | 1 | 9.60 |
| CHEMBL3707247 | OZANIMOD | 4.0 | 1 | 9.40 |
| CHEMBL2336071 | SIPONIMOD | 4.0 | 1 | 9.40 |
| CHEMBL5411968 | — | — | 1 | 9.10 |
| CHEMBL4297505 | CENERIMOD | 3.0 | 1 | 9.00 |
| CHEMBL5438034 | — | — | 1 | 8.70 |
| CHEMBL3358920 | ETRASIMOD | 4.0 | 1 | 8.20 |
| CHEMBL4297350 | ASP-4058 | 1.0 | 1 | 8.10 |
| CHEMBL1096146 | PONESIMOD | 4.0 | 1 | 8.00 |
| CHEMBL4097139 | ICANBELIMOD | 2.0 | 1 | 8.00 |
| CHEMBL225155 | — | — | 1 | 7.90 |
| CHEMBL4297542 | GSK-2018682 | 1.0 | 1 | 7.70 |
| CHEMBL3741589 | — | — | 1 | 6.40 |
| CHEMBL5413017 | — | — | 1 | 6.30 |
| CHEMBL314854 | FINGOLIMOD | 4.0 | 1 | 6.10 |
| CHEMBL5410785 | — | — | 1 | 5.60 |
| CHEMBL224720 | — | — | 1 | 5.50 |
| CHEMBL3960697 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4093489 | — | EC50 | = | 0.02754 | nM | 10.56 |
| CHEMBL3707375 | AMISELIMOD | EC50 | = | 0.07943 | nM | 10.10 |
| CHEMBL3899384 | — | EC50 | = | 0.2512 | nM | 9.60 |
| CHEMBL3707247 | OZANIMOD | EC50 | = | 0.3981 | nM | 9.40 |
| CHEMBL2336071 | SIPONIMOD | EC50 | = | 0.3981 | nM | 9.40 |
| CHEMBL5411968 | — | EC50 | = | 0.7943 | nM | 9.10 |
| CHEMBL4297505 | CENERIMOD | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5438034 | — | EC50 | = | 1.995 | nM | 8.70 |
| CHEMBL3358920 | ETRASIMOD | EC50 | = | 6.31 | nM | 8.20 |
| CHEMBL4297350 | ASP-4058 | EC50 | = | 7.943 | nM | 8.10 |
| CHEMBL1096146 | PONESIMOD | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4097139 | ICANBELIMOD | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL225155 | — | EC50 | = | 12.59 | nM | 7.90 |
| CHEMBL4297542 | GSK-2018682 | EC50 | = | 19.95 | nM | 7.70 |
| CHEMBL3741589 | — | EC50 | = | 398.11 | nM | 6.40 |
| CHEMBL5413017 | — | EC50 | = | 501.19 | nM | 6.30 |
| CHEMBL314854 | FINGOLIMOD | EC50 | = | 794.33 | nM | 6.10 |
| CHEMBL5410785 | — | EC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL224720 | — | EC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL3960697 | — | EC50 | = | 0.007943 | nM | - |