Compound Detail
CHEMBL4297505
CENERIMOD 🧪 Phase III
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🧪 Phase III
Basic Information
| ChEMBL ID | CHEMBL4297505 |
| Name | CENERIMOD |
| Phase | Phase III |
| Structure Type | MOL |
| InChI Key | KJKKMMMRWISKRF-FQEVSTJZSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
3
Known Names
3
Indications
1
Mechanisms
Molecular Properties
453.5
MW (Da)
4.07
ALogP
8
HBA
2
HBD
110.7
PSA (Ų)
0.50
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Sphingosine 1-phosphate receptor Edg-1 modulator | MODULATOR | Sphingosine 1-phosphate receptor 1 | ✓ | ✓ |
Indications
Lupus Erythematosus, Systemic Kidney Diseases Liver Diseases
Activity Summary
EC50 1 meas. best 9.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sphingosine 1-phosphate receptor 1 CHEMBL4333 | EC50 | 9.0 | 9.0 | 1.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sphingosine 1-phosphate receptor 1 | EC50 | = | 1.0 | nM | 9.0 | Modulation of S1PR1 (unknown origin) | 36758307 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
| 36758307 | 10.1016/j.ejmech.2023.115182 | Sphingosine 1-phosphate receptor 1 | 1 |
Data from ChEMBL 36 via Core Engine