Assay Detail
Binding
CHEMBL5387732
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human JNK3 using ATF2 peptide as substrate incubated for 40 mins in presence of gamma-33-P-ATP by scintillation counting method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The structure-based optimization of 3-substituted indolin-2-one derivatives as potent and isoform-selective c-Jun N-terminal kinase 3 (JNK3) inhibitors and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.35 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5416936 | — | — | 1 | 7.89 |
| CHEMBL5402716 | — | — | 1 | 7.57 |
| CHEMBL5406652 | — | — | 1 | 7.11 |
| CHEMBL5432203 | — | — | 1 | 7.11 |
| CHEMBL7064 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5416936 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5402716 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5406652 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL5432203 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL7064 | — | IC50 | = | 90.0 | nM | 7.05 |