Assay Detail
Toxicity
CHEMBL5387922
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Cytotoxicity against mouse NIH/3T3 cells incubated for 72 hrs by SRB assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Mus musculus |
| Cell Type | NIH3T3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Asiatic acid as a leading structure for derivatives combining sub-nanomolar cytotoxicity, high selectivity, and the ability to overcome drug resistance in human preclinical tumor models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.87 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5422662 | — | — | 1 | 7.19 |
| CHEMBL4281011 | — | — | 1 | 6.75 |
| CHEMBL5400445 | — | — | 1 | 5.84 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.77 |
| CHEMBL4280590 | — | — | 1 | 5.75 |
| CHEMBL3785137 | — | — | 1 | 5.21 |
| CHEMBL404313 | ASIATIC ACID | — | 1 | 4.58 |
| CHEMBL428971 | RHODAMINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5422662 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4281011 | — | EC50 | = | 178.0 | nM | 6.75 |
| CHEMBL5400445 | — | EC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL53463 | DOXORUBICIN | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4280590 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3785137 | — | EC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL404313 | ASIATIC ACID | EC50 | = | 26200.0 | nM | 4.58 |
| CHEMBL428971 | RHODAMINE | EC50 | > | 30000.0 | nM | - |