Assay Detail
Functional
CHEMBL5387927
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human LS1034 cell spheroids incubated for 7 days by luciferase based assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LS-1034 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Asiatic acid as a leading structure for derivatives combining sub-nanomolar cytotoxicity, high selectivity, and the ability to overcome drug resistance in human preclinical tumor models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.79 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5422662 | — | — | 1 | 8.03 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 6.96 |
| CHEMBL481 | IRINOTECAN | 4.0 | 1 | 5.39 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | - |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5422662 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL481 | IRINOTECAN | IC50 | = | 4090.0 | nM | 5.39 |
| CHEMBL53463 | DOXORUBICIN | IC50 | - | — | - | |
| CHEMBL428647 | PACLITAXEL | IC50 | - | — | - |