Assay Detail
Binding
CHEMBL5388285
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 15N-labeled NSD2 (953 to 1240 residues) (unknown origin) expressed in Escherichia coli BL21 DE3 using H3K36 as substrate incubated for 60 mins by Alphascreen assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Histone-lysine N-methyltransferase NSD2 (CHEMBL3108645) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent advances in nuclear receptor-binding SET domain 2 (NSD2) inhibitors: An update and perspectives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.19 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5441106 | — | — | 1 | 5.75 |
| CHEMBL3414624 | — | — | 1 | 5.48 |
| CHEMBL1214186 | SINEFUNGIN | 2.0 | 1 | 4.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5441106 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3414624 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL1214186 | SINEFUNGIN | IC50 | = | 46000.0 | nM | 4.34 |