Assay Detail
Binding
CHEMBL5388295
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NSD2 in human CGTH-W-1 cells assessed as reduction in H3K36me2 level incubated for 72 hrs by ELISA
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CGTH-W-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Histone-lysine N-methyltransferase NSD2 (CHEMBL3108645) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent advances in nuclear receptor-binding SET domain 2 (NSD2) inhibitors: An update and perspectives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.69 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5438639 | — | — | 1 | 7.92 |
| CHEMBL5422710 | — | — | 1 | 7.75 |
| CHEMBL5437594 | — | — | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5438639 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5422710 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5437594 | — | IC50 | = | 40.0 | nM | 7.40 |