Assay Detail
Binding
CHEMBL5388300
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human biotinylated NSD2 (208 to 368 residues) expressed in Escherichia coli BL21(DE3) by SPR assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Histone-lysine N-methyltransferase NSD2 (CHEMBL3108645) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent advances in nuclear receptor-binding SET domain 2 (NSD2) inhibitors: An update and perspectives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 6.75 | 7.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5200945 | — | — | 1 | 7.04 |
| CHEMBL5401805 | — | — | 1 | 6.46 |
| CHEMBL5430212 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5200945 | — | Kd | = | 91.0 | nM | 7.04 |
| CHEMBL5401805 | — | Kd | = | 349.0 | nM | 6.46 |
| CHEMBL5430212 | — | Kd | > | 20000.0 | nM | - |