Assay Detail
Functional
CHEMBL5388522
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human LPA1 receptor expressed in CHO cells assessed as inhibition of LPA-induced calcium mobilization pretreated for 15 mins followed by LPA stimulation by FLIPR analysis
62
Total Activities
59
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Potent, Selective, and Orally Bioavailable Tool Compound for Probing the Role of Lysophosphatidic Acid Type 2 Receptor Antagonists in Fibrotic Disorders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 62 | 4.83 | 6.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5413416 | — | — | 1 | 6.09 |
| CHEMBL5401368 | — | — | 2 | 5.27 |
| CHEMBL5418117 | — | — | 1 | 5.25 |
| CHEMBL5398116 | — | — | 1 | 5.06 |
| CHEMBL5439647 | — | — | 1 | 5.02 |
| CHEMBL256470 | — | — | 1 | 5.01 |
| CHEMBL5399781 | — | — | 2 | 5.00 |
| CHEMBL5406143 | — | — | 1 | 4.99 |
| CHEMBL5409858 | — | — | 1 | 4.98 |
| CHEMBL5403072 | — | — | 1 | 4.98 |
| CHEMBL5396575 | — | — | 1 | 4.98 |
| CHEMBL5419697 | — | — | 1 | 4.91 |
| CHEMBL5434862 | — | — | 2 | 4.90 |
| CHEMBL5407919 | — | — | 1 | 4.89 |
| CHEMBL5427680 | — | — | 1 | 4.82 |
| CHEMBL5404276 | — | — | 1 | 4.82 |
| CHEMBL5429482 | — | — | 1 | 4.81 |
| CHEMBL5405375 | — | — | 1 | 4.77 |
| CHEMBL5435934 | — | — | 1 | 4.75 |
| CHEMBL5436208 | — | — | 1 | 4.74 |
| CHEMBL5410659 | — | — | 1 | 4.74 |
| CHEMBL5438524 | — | — | 1 | 4.72 |
| CHEMBL5417982 | — | — | 1 | 4.72 |
| CHEMBL5396746 | — | — | 1 | 4.72 |
| CHEMBL5421405 | — | — | 1 | 4.69 |
| CHEMBL5407268 | — | — | 1 | 4.69 |
| CHEMBL5405856 | — | — | 1 | 4.67 |
| CHEMBL5418255 | — | — | 1 | 4.66 |
| CHEMBL5433347 | — | — | 1 | 4.66 |
| CHEMBL5428223 | — | — | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5413416 | — | IC50 | = | 812.83 | nM | 6.09 |
| CHEMBL5401368 | — | IC50 | = | 5370.32 | nM | 5.27 |
| CHEMBL5418117 | — | IC50 | = | 5623.41 | nM | 5.25 |
| CHEMBL5398116 | — | IC50 | = | 8709.64 | nM | 5.06 |
| CHEMBL5401368 | — | IC50 | = | 9120.11 | nM | 5.04 |
| CHEMBL5439647 | — | IC50 | = | 9549.93 | nM | 5.02 |
| CHEMBL256470 | — | IC50 | = | 9772.37 | nM | 5.01 |
| CHEMBL5399781 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5406143 | — | IC50 | = | 10232.93 | nM | 4.99 |
| CHEMBL5409858 | — | IC50 | = | 10471.29 | nM | 4.98 |
| CHEMBL5403072 | — | IC50 | = | 10471.29 | nM | 4.98 |
| CHEMBL5396575 | — | IC50 | = | 10471.29 | nM | 4.98 |
| CHEMBL5399781 | — | IC50 | = | 11748.98 | nM | 4.93 |
| CHEMBL5419697 | — | IC50 | = | 12302.69 | nM | 4.91 |
| CHEMBL5434862 | — | IC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL5407919 | — | IC50 | = | 12882.5 | nM | 4.89 |
| CHEMBL5404276 | — | IC50 | = | 15135.61 | nM | 4.82 |
| CHEMBL5427680 | — | IC50 | = | 15135.61 | nM | 4.82 |
| CHEMBL5429482 | — | IC50 | = | 15488.17 | nM | 4.81 |
| CHEMBL5405375 | — | IC50 | = | 16982.44 | nM | 4.77 |
| CHEMBL5435934 | — | IC50 | = | 17782.79 | nM | 4.75 |
| CHEMBL5436208 | — | IC50 | = | 18197.01 | nM | 4.74 |
| CHEMBL5410659 | — | IC50 | = | 18197.01 | nM | 4.74 |
| CHEMBL5396746 | — | IC50 | = | 19054.61 | nM | 4.72 |
| CHEMBL5438524 | — | IC50 | = | 19054.61 | nM | 4.72 |
| CHEMBL5417982 | — | IC50 | = | 19054.61 | nM | 4.72 |
| CHEMBL5421405 | — | IC50 | = | 20417.38 | nM | 4.69 |
| CHEMBL5407268 | — | IC50 | = | 20417.38 | nM | 4.69 |
| CHEMBL5405856 | — | IC50 | = | 21379.62 | nM | 4.67 |
| CHEMBL5418255 | — | IC50 | = | 21877.62 | nM | 4.66 |
| CHEMBL5433347 | — | IC50 | = | 21877.62 | nM | 4.66 |
| CHEMBL5428223 | — | IC50 | = | 23988.33 | nM | 4.62 |
| CHEMBL5429728 | — | IC50 | = | 27542.29 | nM | 4.56 |
| CHEMBL5408817 | — | IC50 | = | 30902.95 | nM | 4.51 |
| CHEMBL5440548 | — | IC50 | = | 31622.78 | nM | 4.50 |
| CHEMBL5411589 | — | IC50 | = | 31622.78 | nM | 4.50 |
| CHEMBL5396450 | — | IC50 | = | 33113.11 | nM | 4.48 |
| CHEMBL5411654 | — | IC50 | = | 36307.81 | nM | 4.44 |
| CHEMBL5434883 | — | IC50 | = | 40738.03 | nM | 4.39 |
| CHEMBL5399159 | — | IC50 | > | 50118.72 | nM | - |
| CHEMBL5405450 | — | IC50 | > | 50118.72 | nM | - |
| CHEMBL5427161 | — | IC50 | > | 50118.72 | nM | - |
| CHEMBL5395244 | — | IC50 | > | 50118.72 | nM | - |
| CHEMBL5424571 | — | IC50 | > | 50118.72 | nM | - |
| CHEMBL5434096 | — | IC50 | > | 50118.72 | nM | - |
| CHEMBL5418199 | — | IC50 | > | 50118.72 | nM | - |
| CHEMBL5424251 | — | IC50 | > | 5011.87 | nM | - |
| CHEMBL5424662 | — | IC50 | > | 50118.72 | nM | - |
| CHEMBL5397550 | — | IC50 | > | 501.19 | nM | - |
| CHEMBL5393777 | — | IC50 | > | 50118.72 | nM | - |