Assay Detail
Binding
CHEMBL5388997
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of fluorescent probe (R)-(+)-ethyl 5-amino2-methyl-1,2-dihydro-3-phenylpyrido[3,4-b]pyrazin-7-ylcarbamate from tubulin colchicine binding site (unknown origin) assessed as dissociation constant
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
PM534, an Optimized Target-Protein Interaction Strategy through the Colchicine Site of Tubulin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 7.06 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5410715 | — | — | 1 | 8.52 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 6.85 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5410715 | — | Kd | = | 3.0 | nM | 8.52 |
| CHEMBL67 | COMBRETASTATIN A4 | Kd | = | 140.0 | nM | 6.85 |
| CHEMBL107 | COLCHICINE | Kd | = | 1500.0 | nM | 5.82 |