Assay Detail
Functional
CHEMBL5389548
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human SK-BR-3 cells harboring wildtype PI3Kalpha assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Glo 2.0 luminescent cell viability assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-BR-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3Kα Mutant Protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.12 | 5.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5404456 | — | — | 1 | 5.37 |
| CHEMBL5402470 | — | — | 1 | 5.05 |
| CHEMBL5419204 | — | — | 1 | 5.04 |
| CHEMBL5414256 | — | — | 1 | 5.00 |
| CHEMBL5436038 | — | — | 1 | - |
| CHEMBL5423227 | — | — | 1 | - |
| CHEMBL5440814 | — | — | 1 | - |
| CHEMBL5401780 | — | — | 1 | - |
| CHEMBL5411976 | — | — | 1 | - |
| CHEMBL5406950 | — | — | 1 | - |
| CHEMBL5424195 | — | — | 1 | - |
| CHEMBL5408522 | — | — | 1 | - |
| CHEMBL5437679 | — | — | 1 | - |
| CHEMBL5413908 | — | — | 1 | - |
| CHEMBL5431134 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5404456 | — | IC50 | = | 4309.0 | nM | 5.37 |
| CHEMBL5402470 | — | IC50 | = | 8972.0 | nM | 5.05 |
| CHEMBL5419204 | — | IC50 | = | 9082.0 | nM | 5.04 |
| CHEMBL5414256 | — | IC50 | = | 9941.0 | nM | 5.00 |
| CHEMBL5436038 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5423227 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5440814 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5401780 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5411976 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5406950 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5424195 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5408522 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5437679 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5413908 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5431134 | — | IC50 | > | 10000.0 | nM | - |