Assay Detail
Binding
CHEMBL5389686
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant SARS-CoV-2 Native Main protease expressed in Escherichia coli using using Edans-labeled substrate by FRET-based assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL4523582) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
An ascidian Polycarpa aurata-derived pan-inhibitor against coronaviruses targeting M<sup>pro</sup>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.85 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2315036 | — | — | 1 | 7.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2315036 | — | IC50 | = | 14.0 | nM | 7.85 |