Assay Detail
Binding
CHEMBL5389693
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Inhibition of SARS-CoV-2 Main protease
4
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL4523582) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
An ascidian Polycarpa aurata-derived pan-inhibitor against coronaviruses targeting M<sup>pro</sup>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.66 | 7.52 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5403045 | — | — | 2 | 7.52 |
| CHEMBL403516 | ACETYLSHIKONIN | — | 1 | 6.46 |
| CHEMBL397309 | BETA-HYDROXYISOVALERYLSHIKONIN | — | 1 | 5.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5403045 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL403516 | ACETYLSHIKONIN | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL397309 | BETA-HYDROXYISOVALERYLSHIKONIN | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL5403045 | — | Inhibition | - | % | - |