Assay Detail
Functional
CHEMBL5389985
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reversal of multidrug resistance in multidrug resistant mouse L5178Y cells transfected with human ABCB1 assessed as reduction in cell viability incubated for 72 hrs by MTT assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L5178Y |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Nitrogen-containing andrographolide derivatives with multidrug resistance reversal effects in cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 4.57 | 5.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5406701 | — | — | 1 | 5.26 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.17 |
| CHEMBL5399067 | — | — | 1 | 5.04 |
| CHEMBL5408782 | — | — | 1 | 4.93 |
| CHEMBL5415890 | — | — | 1 | 4.93 |
| CHEMBL5441053 | — | — | 1 | 4.92 |
| CHEMBL186141 | ANDROGRAPHOLIDE | 3.0 | 1 | 4.83 |
| CHEMBL5437345 | — | — | 1 | 4.83 |
| CHEMBL5412874 | — | — | 1 | 4.82 |
| CHEMBL5406299 | — | — | 1 | 4.82 |
| CHEMBL1933972 | — | — | 1 | 4.72 |
| CHEMBL5416984 | — | — | 1 | 4.63 |
| CHEMBL5435157 | — | — | 1 | 4.39 |
| CHEMBL5408508 | — | — | 1 | 4.33 |
| CHEMBL5436558 | — | — | 1 | 4.29 |
| CHEMBL5402015 | — | — | 1 | 4.29 |
| CHEMBL5410305 | — | — | 1 | 4.27 |
| CHEMBL5407580 | — | — | 1 | 4.26 |
| CHEMBL5440240 | — | — | 1 | 4.23 |
| CHEMBL5437388 | — | — | 1 | 4.17 |
| CHEMBL5429934 | — | — | 1 | 4.17 |
| CHEMBL5414420 | — | — | 1 | 4.16 |
| CHEMBL5435786 | — | — | 1 | 4.15 |
| CHEMBL5408646 | — | — | 1 | 4.09 |
| CHEMBL5402657 | — | — | 1 | - |
| CHEMBL5435785 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5406701 | — | IC50 | = | 5470.0 | nM | 5.26 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 6820.0 | nM | 5.17 |
| CHEMBL5399067 | — | IC50 | = | 9040.0 | nM | 5.04 |
| CHEMBL5408782 | — | IC50 | = | 11770.0 | nM | 4.93 |
| CHEMBL5415890 | — | IC50 | = | 11780.0 | nM | 4.93 |
| CHEMBL5441053 | — | IC50 | = | 12020.0 | nM | 4.92 |
| CHEMBL186141 | ANDROGRAPHOLIDE | IC50 | = | 14950.0 | nM | 4.83 |
| CHEMBL5437345 | — | IC50 | = | 14950.0 | nM | 4.83 |
| CHEMBL5412874 | — | IC50 | = | 15310.0 | nM | 4.82 |
| CHEMBL5406299 | — | IC50 | = | 15280.0 | nM | 4.82 |
| CHEMBL1933972 | — | IC50 | = | 19200.0 | nM | 4.72 |
| CHEMBL5416984 | — | IC50 | = | 23420.0 | nM | 4.63 |
| CHEMBL5435157 | — | IC50 | = | 40890.0 | nM | 4.39 |
| CHEMBL5408508 | — | IC50 | = | 47360.0 | nM | 4.33 |
| CHEMBL5436558 | — | IC50 | = | 51290.0 | nM | 4.29 |
| CHEMBL5402015 | — | IC50 | = | 51310.0 | nM | 4.29 |
| CHEMBL5410305 | — | IC50 | = | 54180.0 | nM | 4.27 |
| CHEMBL5407580 | — | IC50 | = | 54830.0 | nM | 4.26 |
| CHEMBL5440240 | — | IC50 | = | 58720.0 | nM | 4.23 |
| CHEMBL5437388 | — | IC50 | = | 67390.0 | nM | 4.17 |
| CHEMBL5429934 | — | IC50 | = | 67600.0 | nM | 4.17 |
| CHEMBL5414420 | — | IC50 | = | 70030.0 | nM | 4.16 |
| CHEMBL5435786 | — | IC50 | = | 71510.0 | nM | 4.15 |
| CHEMBL5408646 | — | IC50 | = | 80990.0 | nM | 4.09 |
| CHEMBL5402657 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5435785 | — | IC50 | > | 100000.0 | nM | - |