Assay Detail
Binding
CHEMBL5390002
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Displacement of fluorochrome-tagged estrogen from human recombinant estrogen receptor-alpha incubated for 2 hr by competitive binding based microplate reader analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, <i>in vitro</i> and <i>in silico</i> evaluation of indole-based tetrazole derivatives as putative anti-breast cancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.22 | 8.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5430117 | — | — | 1 | 8.23 |
| CHEMBL5409715 | — | — | 1 | 6.96 |
| CHEMBL46740 | BAZEDOXIFENE | 4.0 | 1 | 6.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5430117 | — | IC50 | = | 5.826 | nM | 8.23 |
| CHEMBL5409715 | — | IC50 | = | 110.6 | nM | 6.96 |
| CHEMBL46740 | BAZEDOXIFENE | IC50 | = | 339.2 | nM | 6.47 |