Assay Detail
Binding
CHEMBL5390757
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Inhibition of SARS-CoV-2 3CLpro incubated for 4 hrs
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL4523582) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Cyclotheonellazoles D-I, Potent Elastase Inhibitory Thiazole-Containing Cyclic Peptides from <i>Theonella</i> sp. (2131).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.05 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51085 | EBSELEN | 3.0 | 1 | 8.00 |
| CHEMBL3427166 | — | — | 1 | 7.00 |
| CHEMBL5414337 | — | — | 1 | 5.96 |
| CHEMBL5430373 | — | — | 1 | 5.34 |
| CHEMBL5394627 | — | — | 1 | 5.21 |
| CHEMBL5418049 | — | — | 1 | 4.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51085 | EBSELEN | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3427166 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5414337 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5430373 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL5394627 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL5418049 | — | IC50 | = | 16100.0 | nM | 4.79 |