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Assay Detail

CHEMBL5390971

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of tubulin polymerization (unknown origin) incubated for 1 hr
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Tubulin (CHEMBL2095182)
Type PROTEIN COMPLEX GROUP
Organism Homo sapiens

Publication

Benzimidazole derivatives as tubulin polymerization inhibitors: Design, synthesis and in vitro cytotoxicity studies.
Laxmikeshav K, Rahman Z, Mahale A, Gurukkala Valapil D, Sharma P, George J, Phanindranath R, Dandekar MP, Kulkarni OP, Nagesh N, Shankaraiah N.
Bioorg Med Chem Lett (2023) 96 : 129494 -129494
PubMed 37797804 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.25 5.25
Inhibition 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5396880 2 5.25

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5396880 IC50 = 5650.0 nM 5.25
CHEMBL5396880 Inhibition - % -