Assay Detail
Binding
CHEMBL5392152
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NLRP3 in mouse J774A.1 cells assessed as reduction of IL-1beta production
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | J774.A1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NACHT, LRR and PYD domains-containing protein 3 (CHEMBL3779755) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Recent Progress and Prospects of Small Molecules for NLRP3 Inflammasome Inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.93 | 6.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5436913 | — | — | 1 | 6.04 |
| CHEMBL403183 | — | — | 1 | 5.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5436913 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL403183 | — | IC50 | = | 1540.0 | nM | 5.81 |