Assay Detail
Binding
CHEMBL5392889
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Binding affinity to histamine H3 receptor (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Tritiated Radioligand with High Affinity and Selectivity for the Histamine H<sub>3</sub> Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.45 | 9.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129542 | JNJ-5207852 | — | 1 | 9.20 |
| CHEMBL462605 | PITOLISANT | 4.0 | 1 | 8.60 |
| CHEMBL268229 | — | — | 1 | 8.40 |
| CHEMBL11919 | — | — | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129542 | JNJ-5207852 | Ki | = | 0.631 | nM | 9.20 |
| CHEMBL462605 | PITOLISANT | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL268229 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL11919 | — | Ki | = | 25.12 | nM | 7.60 |