Assay Detail
Binding
CHEMBL5392891
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]NAMH from human C-terminal Nluc-tagged Halo tag fused between T229/F348 residue histamine H3 receptor expressed in HEK293-A cells incubated for 2 hrs by scintillation counter analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293-A |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Tritiated Radioligand with High Affinity and Selectivity for the Histamine H<sub>3</sub> Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 7.80 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL268229 | — | — | 1 | 8.30 |
| CHEMBL11919 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL268229 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL11919 | — | Ki | = | 50.12 | nM | 7.30 |