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Assay Detail

CHEMBL5393722

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antagonist activity at recombinant human GPR65 expressed in human 1321N1 cells assessed as reduction in cAMP level incubated for 30 mins by HTRF assay
ChEMBL ↗
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type 1321N1
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Psychosine receptor (CHEMBL3714081) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

N-(pyridin-2-yl)-6,7,8,9-tetrahydro-5h-5,8-epiminocyclohepta[c]pyridine-10-carboxamide derivatives and similar compounds as gpr65 modulators for the treatment of cancer
(2022)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 51 6.30 6.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5433744 — — 1 6.30
CHEMBL5420624 — — 1 6.30
CHEMBL5437369 — — 1 6.30
CHEMBL5435598 — — 1 6.30
CHEMBL5440522 — — 1 6.30
CHEMBL5427600 — — 1 6.30
CHEMBL5407784 — — 1 6.30
CHEMBL5404390 — — 1 6.30
CHEMBL5417806 — — 1 6.30
CHEMBL5422604 — — 1 6.30
CHEMBL5421727 — — 1 6.30
CHEMBL5403385 — — 1 6.30
CHEMBL5424723 — — 1 6.30
CHEMBL5400100 — — 1 6.30
CHEMBL5431825 — — 1 6.30
CHEMBL5402018 — — 1 6.30
CHEMBL5400228 — — 1 6.30
CHEMBL5406035 — — 1 6.30
CHEMBL5398106 — — 1 6.30
CHEMBL5406392 — — 1 6.30
CHEMBL5413335 — — 1 6.30
CHEMBL5437775 — — 1 6.30
CHEMBL5394504 — — 1 -
CHEMBL5401751 — — 1 -
CHEMBL5436735 — — 1 -
CHEMBL5440713 — — 1 -
CHEMBL5394647 — — 1 -
CHEMBL5425337 — — 1 -
CHEMBL5403942 — — 1 -
CHEMBL5437080 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5433744 — IC50 = 500.0 nM 6.30
CHEMBL5424723 — IC50 = 500.0 nM 6.30
CHEMBL5420624 — IC50 = 500.0 nM 6.30
CHEMBL5437369 — IC50 = 500.0 nM 6.30
CHEMBL5435598 — IC50 = 500.0 nM 6.30
CHEMBL5440522 — IC50 = 500.0 nM 6.30
CHEMBL5427600 — IC50 = 500.0 nM 6.30
CHEMBL5407784 — IC50 = 500.0 nM 6.30
CHEMBL5404390 — IC50 = 500.0 nM 6.30
CHEMBL5417806 — IC50 = 500.0 nM 6.30
CHEMBL5422604 — IC50 = 500.0 nM 6.30
CHEMBL5421727 — IC50 = 500.0 nM 6.30
CHEMBL5403385 — IC50 = 500.0 nM 6.30
CHEMBL5437775 — IC50 = 500.0 nM 6.30
CHEMBL5400100 — IC50 = 500.0 nM 6.30
CHEMBL5431825 — IC50 = 500.0 nM 6.30
CHEMBL5402018 — IC50 = 500.0 nM 6.30
CHEMBL5400228 — IC50 = 500.0 nM 6.30
CHEMBL5406035 — IC50 = 500.0 nM 6.30
CHEMBL5398106 — IC50 = 500.0 nM 6.30
CHEMBL5406392 — IC50 = 500.0 nM 6.30
CHEMBL5413335 — IC50 = 500.0 nM 6.30
CHEMBL5431506 — IC50 > 5000.0 nM -
CHEMBL5427787 — IC50 > 5000.0 nM -
CHEMBL5436675 — IC50 < 500.0 nM -
CHEMBL5424538 — IC50 < 500.0 nM -
CHEMBL5402719 — IC50 < 500.0 nM -
CHEMBL5427106 — IC50 < 500.0 nM -
CHEMBL5422033 — IC50 > 5000.0 nM -
CHEMBL5416782 — IC50 < 500.0 nM -
CHEMBL5414586 — IC50 < 500.0 nM -
CHEMBL5404920 — IC50 < 500.0 nM -
CHEMBL5426210 — IC50 < 500.0 nM -
CHEMBL5406926 — IC50 < 500.0 nM -
CHEMBL5397195 — IC50 < 500.0 nM -
CHEMBL5432448 — IC50 > 5000.0 nM -
CHEMBL5427717 — IC50 < 500.0 nM -
CHEMBL5415869 — IC50 < 500.0 nM -
CHEMBL5397702 — IC50 < 500.0 nM -
CHEMBL5402322 — IC50 < 500.0 nM -
CHEMBL5432962 — IC50 > 5000.0 nM -
CHEMBL5413259 — IC50 > 5000.0 nM -
CHEMBL5437080 — IC50 < 500.0 nM -
CHEMBL5403942 — IC50 < 500.0 nM -
CHEMBL5425337 — IC50 < 500.0 nM -
CHEMBL5394647 — IC50 < 500.0 nM -
CHEMBL5440713 — IC50 < 500.0 nM -
CHEMBL5436735 — IC50 < 500.0 nM -
CHEMBL5401751 — IC50 < 500.0 nM -
CHEMBL5394504 — IC50 > 5000.0 nM -