Assay Detail
Binding
CHEMBL5446057
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity On-target Cellular interaction: (STAT-dependent luciferase reporter assay in PBMCs (IFNxcexb1-stimulation, measuring STAT5 phosphorylation in CD3+ T-cells as end point, TYK2/JAK1 dependent signaling)) EUB0001543a TYK2
1
Total Activities
1
Compounds Tested
1
Activity Types
3
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CD3+ T-cells |
| Category | Affinity on-target cellular assay |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Non-receptor tyrosine-protein kinase TYK2 (CHEMBL3553) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Affinity On-target Cellular Literature for EUbOPEN Chemogenomic Library
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.70 | 8.70 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| Mode of action | Mode of action | - | — | Allosteric inhibitor |
| Protein family | Protein family | - | — | Protein Kinase |
| Recommended concentration | Recommended concentration | 100.0 | nM | — |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4435170 | DEUCRAVACITINIB | 4.0 | 1 | 8.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4435170 | DEUCRAVACITINIB | IC50 | = | 2.0 | nM | 8.70 |