Assay Detail
Binding
CHEMBL5500435
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Antagonist activity at AR in human LNCaP cells incubated for 24 hrs by Western blotting analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | LNCaP |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and clinical application of small-molecule drugs approved to treat prostatic cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.62 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3183409 | APALUTAMIDE | 4.0 | 1 | 7.80 |
| CHEMBL1082407 | ENZALUTAMIDE | 4.0 | 1 | 7.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3183409 | APALUTAMIDE | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1082407 | ENZALUTAMIDE | IC50 | = | 36.0 | nM | 7.44 |