Assay Detail
Functional
CHEMBL5500480
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The potential of marine-derived piperazine alkaloids: Sources, structures and bioactivities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.30 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5542380 | — | — | 1 | 9.40 |
| CHEMBL5557094 | — | — | 1 | 9.24 |
| CHEMBL554604 | JORUNNAMYCIN C | — | 1 | 8.82 |
| CHEMBL451147 | RENIERAMYCIN M | — | 1 | 8.10 |
| CHEMBL549905 | JOURNNAMYCIN A | — | 1 | 7.89 |
| CHEMBL5558598 | — | — | 1 | 6.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5542380 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL5557094 | — | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL554604 | JORUNNAMYCIN C | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL451147 | RENIERAMYCIN M | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL549905 | JOURNNAMYCIN A | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5558598 | — | IC50 | = | 455.0 | nM | 6.34 |