Assay Detail
Binding
CHEMBL5500912
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant SIRT2 (unknown origin) deacetylase activity using Ac-RHKK(Ac)-MCA as substrate incubated for 60 mins in presence of NAD by fluorogenic assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacetylase sirtuin-2 (CHEMBL4462) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Ligand-based design and synthesis of new trityl histamine and trityl cysteamine derivatives as SIRT2 inhibitors for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.02 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3770903 | — | — | 1 | 6.92 |
| CHEMBL5555254 | — | — | 1 | 5.25 |
| CHEMBL5518043 | — | — | 1 | 5.12 |
| CHEMBL5556453 | — | — | 1 | 5.06 |
| CHEMBL5557521 | — | — | 1 | 5.06 |
| CHEMBL5542326 | — | — | 1 | 5.00 |
| CHEMBL5557139 | — | — | 1 | 4.97 |
| CHEMBL5559510 | — | — | 1 | 4.92 |
| CHEMBL5542871 | — | — | 1 | 4.91 |
| CHEMBL5557325 | — | — | 1 | 4.85 |
| CHEMBL5505900 | — | — | 1 | 4.81 |
| CHEMBL5556326 | — | — | 1 | 4.58 |
| CHEMBL5558060 | — | — | 1 | 4.56 |
| CHEMBL5527915 | — | — | 1 | 4.30 |
| CHEMBL5523388 | — | — | 1 | - |
| CHEMBL5557313 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3770903 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5555254 | — | IC50 | = | 5630.0 | nM | 5.25 |
| CHEMBL5518043 | — | IC50 | = | 7610.0 | nM | 5.12 |
| CHEMBL5556453 | — | IC50 | = | 8620.0 | nM | 5.06 |
| CHEMBL5557521 | — | IC50 | = | 8630.0 | nM | 5.06 |
| CHEMBL5542326 | — | IC50 | = | 9910.0 | nM | 5.00 |
| CHEMBL5557139 | — | IC50 | = | 10610.0 | nM | 4.97 |
| CHEMBL5559510 | — | IC50 | = | 12020.0 | nM | 4.92 |
| CHEMBL5542871 | — | IC50 | = | 12420.0 | nM | 4.91 |
| CHEMBL5557325 | — | IC50 | = | 14180.0 | nM | 4.85 |
| CHEMBL5505900 | — | IC50 | = | 15380.0 | nM | 4.81 |
| CHEMBL5556326 | — | IC50 | = | 26140.0 | nM | 4.58 |
| CHEMBL5558060 | — | IC50 | = | 27280.0 | nM | 4.56 |
| CHEMBL5527915 | — | IC50 | = | 49640.0 | nM | 4.30 |
| CHEMBL5523388 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5557313 | — | IC50 | > | 50000.0 | nM | - |