Assay Detail
Functional
CHEMBL5501110
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell proliferation incubated for 72 hrs by by CCK-8 assay
36
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of pyrido[3,2-d]pyrimidin-6(5H)-one derivatives as checkpoint kinase 1 (CHK1) inhibitors with potent antitumor efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 6.15 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4169078 | SRA-737 | 1.0 | 3 | 8.37 |
| CHEMBL5555304 | — | — | 1 | 7.71 |
| CHEMBL5537107 | — | — | 1 | 7.40 |
| CHEMBL5557443 | — | — | 1 | 7.25 |
| CHEMBL5512468 | — | — | 1 | 6.70 |
| CHEMBL5559220 | — | — | 1 | 6.05 |
| CHEMBL5559032 | — | — | 1 | 5.67 |
| CHEMBL5542176 | — | — | 1 | 5.66 |
| CHEMBL5505924 | — | — | 1 | 5.65 |
| CHEMBL5558685 | — | — | 1 | 5.61 |
| CHEMBL5549887 | — | — | 1 | 5.57 |
| CHEMBL5517635 | — | — | 1 | 5.44 |
| CHEMBL5556405 | — | — | 1 | 5.42 |
| CHEMBL5518101 | — | — | 1 | 5.42 |
| CHEMBL5558334 | — | — | 1 | 5.31 |
| CHEMBL5542757 | — | — | 1 | 5.06 |
| CHEMBL5505862 | — | — | 1 | - |
| CHEMBL5554982 | — | — | 1 | - |
| CHEMBL5557838 | — | — | 1 | - |
| CHEMBL5532069 | — | — | 1 | - |
| CHEMBL5542583 | — | — | 1 | - |
| CHEMBL5549895 | — | — | 1 | - |
| CHEMBL5523531 | — | — | 1 | - |
| CHEMBL5556722 | — | — | 1 | - |
| CHEMBL5555971 | — | — | 1 | - |
| CHEMBL5512549 | — | — | 1 | - |
| CHEMBL5518028 | — | — | 1 | - |
| CHEMBL5542183 | — | — | 1 | - |
| CHEMBL5517974 | — | — | 1 | - |
| CHEMBL5556225 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4169078 | SRA-737 | IC50 | = | 4.31 | nM | 8.37 |
| CHEMBL5555304 | — | IC50 | = | 19.52 | nM | 7.71 |
| CHEMBL5537107 | — | IC50 | = | 39.41 | nM | 7.40 |
| CHEMBL5557443 | — | IC50 | = | 56.5 | nM | 7.25 |
| CHEMBL5512468 | — | IC50 | = | 202.0 | nM | 6.70 |
| CHEMBL4169078 | SRA-737 | IC50 | = | 587.5 | nM | 6.23 |
| CHEMBL5559220 | — | IC50 | = | 883.0 | nM | 6.05 |
| CHEMBL5559032 | — | IC50 | = | 2114.0 | nM | 5.67 |
| CHEMBL5542176 | — | IC50 | = | 2185.0 | nM | 5.66 |
| CHEMBL5505924 | — | IC50 | = | 2227.0 | nM | 5.65 |
| CHEMBL5558685 | — | IC50 | = | 2472.0 | nM | 5.61 |
| CHEMBL5549887 | — | IC50 | = | 2671.0 | nM | 5.57 |
| CHEMBL5517635 | — | IC50 | = | 3633.0 | nM | 5.44 |
| CHEMBL5556405 | — | IC50 | = | 3810.0 | nM | 5.42 |
| CHEMBL5518101 | — | IC50 | = | 3798.0 | nM | 5.42 |
| CHEMBL5558334 | — | IC50 | = | 4875.0 | nM | 5.31 |
| CHEMBL5542757 | — | IC50 | = | 8642.0 | nM | 5.06 |
| CHEMBL5532607 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5527983 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4169078 | SRA-737 | IC50 | > | 10000.0 | nM | - |
| CHEMBL5558141 | — | IC50 | - | — | - | |
| CHEMBL5549978 | — | IC50 | - | — | - | |
| CHEMBL5556225 | — | IC50 | - | — | - | |
| CHEMBL5517974 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5542183 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5518028 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5512549 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5542583 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5532069 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5557838 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5554982 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5505862 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5549895 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5523531 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5555971 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5556722 | — | IC50 | > | 10000.0 | nM | - |