Assay Detail
Functional
CHEMBL5501552
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Cytotoxicity against human HT-1080 cells incubated for 48 hrs by CCK-8 assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-1080 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
ML162 derivatives incorporating a naphthoquinone unit as ferroptosis/apoptosis inducers: Design, synthesis, anti-cancer activity, and drug-resistance reversal evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.49 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1499544 | — | — | 1 | 6.22 |
| CHEMBL5557964 | — | — | 1 | 5.85 |
| CHEMBL5557694 | — | — | 1 | 5.80 |
| CHEMBL5556720 | — | — | 1 | 5.80 |
| CHEMBL5505746 | — | — | 1 | 5.75 |
| CHEMBL5542697 | — | — | 1 | 5.72 |
| CHEMBL5558639 | — | — | 1 | 5.70 |
| CHEMBL5556022 | — | — | 1 | 5.66 |
| CHEMBL5532521 | — | — | 1 | 5.64 |
| CHEMBL5549866 | — | — | 1 | 5.60 |
| CHEMBL5558887 | — | — | 1 | 5.58 |
| CHEMBL5523473 | — | — | 1 | 5.54 |
| CHEMBL5527923 | — | — | 1 | 5.50 |
| CHEMBL5555462 | — | — | 1 | 5.47 |
| CHEMBL5523502 | — | — | 1 | 5.44 |
| CHEMBL5555215 | — | — | 1 | 5.43 |
| CHEMBL5527879 | — | — | 1 | 5.33 |
| CHEMBL5532076 | — | — | 1 | 5.29 |
| CHEMBL5531943 | — | — | 1 | 5.21 |
| CHEMBL5555721 | — | — | 1 | 4.97 |
| CHEMBL5558517 | — | — | 1 | 4.86 |
| CHEMBL5549826 | — | — | 1 | 4.38 |
| CHEMBL5558481 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1499544 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL5557964 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5557694 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5556720 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5505746 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL5542697 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL5558639 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5556022 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL5532521 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL5549866 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL5558887 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL5523473 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL5527923 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL5555462 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL5523502 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL5555215 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL5527879 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL5532076 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL5531943 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL5555721 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL5558517 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL5549826 | — | IC50 | = | 41500.0 | nM | 4.38 |
| CHEMBL5558481 | — | IC50 | > | 30000.0 | nM | - |