Assay Detail
Binding
CHEMBL5501647
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at androgen receptor (unknown origin) transfected in HEK293T cells co-transfected with luciferase reporter gene assessed as inhibition of transcriptional activity incubated for 18 to 20 hrs by luminescence plate reader analysis
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel selective agents for the degradation of AR/AR-V7 to treat advanced prostate cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.94 | 7.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5559421 | — | — | 1 | 7.59 |
| CHEMBL5517689 | — | — | 1 | 7.44 |
| CHEMBL5558125 | — | — | 1 | 7.42 |
| CHEMBL5518016 | — | — | 1 | 7.23 |
| CHEMBL5437141 | — | — | 1 | 7.22 |
| CHEMBL5505831 | — | — | 1 | 7.00 |
| CHEMBL5542890 | — | — | 1 | 6.99 |
| CHEMBL5542581 | — | — | 1 | 6.94 |
| CHEMBL5517813 | — | — | 1 | 6.84 |
| CHEMBL5559204 | — | — | 1 | 6.76 |
| CHEMBL5557813 | — | — | 1 | 6.51 |
| CHEMBL5531958 | — | — | 1 | 6.50 |
| CHEMBL5557418 | — | — | 1 | 6.41 |
| CHEMBL5531949 | — | — | 1 | 6.25 |
| CHEMBL5532063 | — | — | 1 | - |
| CHEMBL5558969 | — | — | 1 | - |
| CHEMBL5523394 | — | — | 1 | - |
| CHEMBL5555049 | — | — | 1 | - |
| CHEMBL5512492 | — | — | 1 | - |
| CHEMBL5557950 | — | — | 1 | - |
| CHEMBL5555724 | — | — | 1 | - |
| CHEMBL5532027 | — | — | 1 | - |
| CHEMBL5527850 | — | — | 1 | - |
| CHEMBL5559036 | — | — | 1 | - |
| CHEMBL5559462 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5559421 | — | IC50 | = | 25.89 | nM | 7.59 |
| CHEMBL5517689 | — | IC50 | = | 36.67 | nM | 7.44 |
| CHEMBL5558125 | — | IC50 | = | 37.65 | nM | 7.42 |
| CHEMBL5518016 | — | IC50 | = | 59.36 | nM | 7.23 |
| CHEMBL5437141 | — | IC50 | = | 60.79 | nM | 7.22 |
| CHEMBL5505831 | — | IC50 | = | 99.54 | nM | 7.00 |
| CHEMBL5542890 | — | IC50 | = | 101.37 | nM | 6.99 |
| CHEMBL5542581 | — | IC50 | = | 115.58 | nM | 6.94 |
| CHEMBL5517813 | — | IC50 | = | 145.98 | nM | 6.84 |
| CHEMBL5559204 | — | IC50 | = | 172.85 | nM | 6.76 |
| CHEMBL5557813 | — | IC50 | = | 311.27 | nM | 6.51 |
| CHEMBL5531958 | — | IC50 | = | 318.84 | nM | 6.50 |
| CHEMBL5557418 | — | IC50 | = | 393.98 | nM | 6.41 |
| CHEMBL5531949 | — | IC50 | = | 569.21 | nM | 6.25 |
| CHEMBL5532063 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5558969 | — | IC50 | - | — | - | |
| CHEMBL5523394 | — | IC50 | - | — | - | |
| CHEMBL5555049 | — | IC50 | - | — | - | |
| CHEMBL5512492 | — | IC50 | - | — | - | |
| CHEMBL5557950 | — | IC50 | - | — | - | |
| CHEMBL5555724 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5532027 | — | IC50 | - | — | - | |
| CHEMBL5527850 | — | IC50 | - | — | - | |
| CHEMBL5559036 | — | IC50 | - | — | - | |
| CHEMBL5559462 | — | IC50 | - | — | - |