Assay Detail
Binding
CHEMBL5501743
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human TLK2 (388 to end residues) using myelin basic protein as substrate incubated for 2 hrs in presence of ATP by ADP-Glo kinase assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase tousled-like 2 (CHEMBL5404) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and optimization of narrow spectrum inhibitors of Tousled like kinase 2 (TLK2) using quantitative structure activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.32 | 7.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5555013 | — | — | 1 | 7.01 |
| CHEMBL5555697 | — | — | 1 | 6.60 |
| CHEMBL258805 | SU-9516 | 1.0 | 1 | 6.55 |
| CHEMBL5542619 | — | — | 1 | 6.35 |
| CHEMBL5542714 | — | — | 1 | 5.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5555013 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL5555697 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL258805 | SU-9516 | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5542619 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL5542714 | — | IC50 | = | 7800.0 | nM | 5.11 |