Assay Detail
Binding
CHEMBL5501848
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Inhibition of FGFR4 (unknown origin) by ELISA
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of N-(4-((6-(3,5- Dimethoxyphenyl)-9H-purine derivatives as irreversible covalent FGFR inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 8.64 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5523644 | — | — | 1 | 9.49 |
| CHEMBL5557389 | — | — | 1 | 9.40 |
| CHEMBL5505760 | — | — | 1 | 9.34 |
| CHEMBL5532250 | — | — | 1 | 9.24 |
| CHEMBL5523440 | — | — | 1 | 9.21 |
| CHEMBL5556836 | — | — | 1 | 9.20 |
| CHEMBL5505810 | — | — | 1 | 9.17 |
| CHEMBL5532164 | — | — | 1 | 9.14 |
| CHEMBL5559147 | — | — | 1 | 9.12 |
| CHEMBL5505915 | — | — | 1 | 9.12 |
| CHEMBL5558932 | — | — | 1 | 9.11 |
| CHEMBL5523406 | — | — | 1 | 8.95 |
| CHEMBL5555122 | — | — | 1 | 8.91 |
| CHEMBL5557676 | — | — | 1 | 8.89 |
| CHEMBL5558861 | — | — | 1 | 8.88 |
| CHEMBL5517632 | — | — | 1 | 8.85 |
| CHEMBL5532206 | — | — | 1 | 8.67 |
| CHEMBL5556891 | — | — | 1 | 8.67 |
| CHEMBL5518070 | — | — | 1 | 8.57 |
| CHEMBL5558636 | — | — | 1 | 8.54 |
| CHEMBL5556420 | — | — | 1 | 8.52 |
| CHEMBL5287545 | — | — | 1 | 8.52 |
| CHEMBL5558713 | — | — | 1 | 8.49 |
| CHEMBL5558293 | — | — | 1 | 8.46 |
| CHEMBL5555515 | — | — | 1 | 8.43 |
| CHEMBL5557920 | — | — | 1 | 8.22 |
| CHEMBL5532298 | — | — | 1 | 8.21 |
| CHEMBL5557395 | — | — | 1 | 8.11 |
| CHEMBL5542848 | — | — | 1 | 7.97 |
| CHEMBL5505873 | — | — | 1 | 7.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5523644 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL5557389 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL5505760 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL5532250 | — | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL5523440 | — | IC50 | = | 0.62 | nM | 9.21 |
| CHEMBL5556836 | — | IC50 | = | 0.63 | nM | 9.20 |
| CHEMBL5505810 | — | IC50 | = | 0.68 | nM | 9.17 |
| CHEMBL5532164 | — | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL5559147 | — | IC50 | = | 0.76 | nM | 9.12 |
| CHEMBL5505915 | — | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL5558932 | — | IC50 | = | 0.77 | nM | 9.11 |
| CHEMBL5523406 | — | IC50 | = | 1.12 | nM | 8.95 |
| CHEMBL5555122 | — | IC50 | = | 1.24 | nM | 8.91 |
| CHEMBL5557676 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL5558861 | — | IC50 | = | 1.31 | nM | 8.88 |
| CHEMBL5517632 | — | IC50 | = | 1.42 | nM | 8.85 |
| CHEMBL5532206 | — | IC50 | = | 2.16 | nM | 8.67 |
| CHEMBL5556891 | — | IC50 | = | 2.16 | nM | 8.67 |
| CHEMBL5518070 | — | IC50 | = | 2.66 | nM | 8.57 |
| CHEMBL5558636 | — | IC50 | = | 2.86 | nM | 8.54 |
| CHEMBL5556420 | — | IC50 | = | 3.05 | nM | 8.52 |
| CHEMBL5287545 | — | IC50 | = | 3.05 | nM | 8.52 |
| CHEMBL5558713 | — | IC50 | = | 3.22 | nM | 8.49 |
| CHEMBL5558293 | — | IC50 | = | 3.46 | nM | 8.46 |
| CHEMBL5555515 | — | IC50 | = | 3.74 | nM | 8.43 |
| CHEMBL5557920 | — | IC50 | = | 5.99 | nM | 8.22 |
| CHEMBL5532298 | — | IC50 | = | 6.13 | nM | 8.21 |
| CHEMBL5557395 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL5542848 | — | IC50 | = | 10.77 | nM | 7.97 |
| CHEMBL5505873 | — | IC50 | = | 13.12 | nM | 7.88 |
| CHEMBL5532156 | — | IC50 | = | 13.98 | nM | 7.85 |
| CHEMBL5505835 | — | IC50 | = | 24.89 | nM | 7.60 |
| CHEMBL3348846 | FEXAGRATINIB | IC50 | = | 369.46 | nM | 6.43 |