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Assay Detail

CHEMBL5502103

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Binding
Inhibition of LIMK1 (unknown origin) assessed as inhibition constant by LanthScreen Eu kinase binding assay
ChEMBL ↗
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

LIM domain kinase 1 (CHEMBL3836) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Tetrahydropyridine LIMK inhibitors: Structure activity studies and biological characterization.
Champiré A, Berabez R, Braka A, Cosson A, Corret J, Girardin C, Serrano A, Aci-Sèche S, Bonnet P, Josselin B, Brindeau P, Ruchaud S, Leguevel R, Chatterjee D, Mathea S, Knapp S, Brion R, Verrecchia F, Vallée B, Plé K, Bénédetti H, Routier S.
Eur J Med Chem (2024) 271 : 116391 -116391
PubMed 38669909 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 46 7.25 8.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5549785 — — 1 8.40
CHEMBL5505895 — — 1 8.15
CHEMBL5517889 — — 1 8.05
CHEMBL5532060 — — 1 7.92
CHEMBL5557696 — — 1 7.89
CHEMBL5555533 — — 1 7.89
CHEMBL5556301 — — 1 7.82
CHEMBL5532314 — — 1 7.82
CHEMBL5532392 — — 1 7.77
CHEMBL5558266 — — 1 7.70
CHEMBL5555123 — — 1 7.68
CHEMBL5555717 — — 1 7.66
CHEMBL5527967 — — 1 7.57
CHEMBL5512526 — — 1 7.55
CHEMBL5558282 — — 1 7.51
CHEMBL5518021 — — 1 7.50
CHEMBL5505781 — — 1 7.39
CHEMBL5558249 — — 1 7.34
CHEMBL5559496 — — 1 7.30
CHEMBL5517995 — — 1 7.29
CHEMBL5557945 — — 1 7.28
CHEMBL5556003 — — 1 7.27
CHEMBL5556171 — — 1 7.24
CHEMBL5555904 — — 1 7.21
CHEMBL5527982 — — 1 7.20
CHEMBL5523494 — — 1 7.12
CHEMBL5505742 — — 1 7.09
CHEMBL5558156 — — 1 7.07
CHEMBL5543002 — — 1 7.05
CHEMBL5555778 — — 1 7.03

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5549785 — Ki = 4.0 nM 8.40
CHEMBL5505895 — Ki = 7.0 nM 8.15
CHEMBL5517889 — Ki = 9.0 nM 8.05
CHEMBL5532060 — Ki = 12.0 nM 7.92
CHEMBL5557696 — Ki = 13.0 nM 7.89
CHEMBL5555533 — Ki = 13.0 nM 7.89
CHEMBL5556301 — Ki = 15.0 nM 7.82
CHEMBL5532314 — Ki = 15.0 nM 7.82
CHEMBL5532392 — Ki = 17.0 nM 7.77
CHEMBL5558266 — Ki = 20.0 nM 7.70
CHEMBL5555123 — Ki = 21.0 nM 7.68
CHEMBL5555717 — Ki = 22.0 nM 7.66
CHEMBL5527967 — Ki = 27.0 nM 7.57
CHEMBL5512526 — Ki = 28.0 nM 7.55
CHEMBL5558282 — Ki = 31.0 nM 7.51
CHEMBL5518021 — Ki = 32.0 nM 7.50
CHEMBL5505781 — Ki = 41.0 nM 7.39
CHEMBL5558249 — Ki = 46.0 nM 7.34
CHEMBL5559496 — Ki = 50.0 nM 7.30
CHEMBL5517995 — Ki = 51.0 nM 7.29
CHEMBL5557945 — Ki = 52.0 nM 7.28
CHEMBL5556003 — Ki = 54.0 nM 7.27
CHEMBL5556171 — Ki = 58.0 nM 7.24
CHEMBL5555904 — Ki = 61.0 nM 7.21
CHEMBL5527982 — Ki = 63.0 nM 7.20
CHEMBL5523494 — Ki = 75.0 nM 7.12
CHEMBL5505742 — Ki = 82.0 nM 7.09
CHEMBL5558156 — Ki = 85.0 nM 7.07
CHEMBL5543002 — Ki = 90.0 nM 7.05
CHEMBL5555778 — Ki = 93.0 nM 7.03
CHEMBL5523630 — Ki = 99.0 nM 7.00
CHEMBL5542680 — Ki = 109.0 nM 6.96
CHEMBL5559348 — Ki = 113.0 nM 6.95
CHEMBL5527949 — Ki = 114.0 nM 6.94
CHEMBL5523367 — Ki = 116.0 nM 6.94
CHEMBL5559361 — Ki = 124.0 nM 6.91
CHEMBL5558061 — Ki = 128.0 nM 6.89
CHEMBL5557712 — Ki = 137.0 nM 6.86
CHEMBL5537084 — Ki = 142.0 nM 6.85
CHEMBL5555016 — Ki = 160.0 nM 6.80
CHEMBL5505930 — Ki = 186.0 nM 6.73
CHEMBL5558493 — Ki = 190.0 nM 6.72
CHEMBL5558427 — Ki = 244.0 nM 6.61
CHEMBL5559217 — Ki = 244.0 nM 6.61
CHEMBL5518111 — Ki = 481.0 nM 6.32
CHEMBL5542800 — Ki = 1420.0 nM 5.85