Assay Detail
Binding
CHEMBL5502143
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PD-1/PD-L1 (unknown origin) interaction incubated for 15 mins by HTRF assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Programmed cell death protein 1/Programmed cell death 1 ligand 1 (CHEMBL4523993) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Improving tumor sensitivity by the introduction of an ester chain to triaryl derivatives targeting PD-1/PD-L1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 7.21 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5527862 | — | — | 1 | 8.92 |
| CHEMBL5542281 | — | — | 1 | 8.70 |
| CHEMBL5555050 | — | — | 1 | 8.65 |
| CHEMBL5505768 | — | — | 1 | 8.58 |
| CHEMBL5523436 | — | — | 1 | 7.88 |
| CHEMBL5517848 | — | — | 1 | 7.76 |
| CHEMBL5532170 | — | — | 1 | 7.62 |
| CHEMBL5555775 | — | — | 1 | 7.59 |
| CHEMBL5505855 | — | — | 1 | 7.57 |
| CHEMBL5518088 | — | — | 1 | 7.56 |
| CHEMBL5517955 | — | — | 1 | 7.40 |
| CHEMBL5555127 | — | — | 1 | 7.26 |
| CHEMBL5532067 | — | — | 1 | 7.19 |
| CHEMBL5555650 | — | — | 1 | 7.14 |
| CHEMBL5527981 | — | — | 1 | 7.11 |
| CHEMBL5557259 | — | — | 1 | 6.96 |
| CHEMBL5512521 | — | — | 1 | 6.95 |
| CHEMBL5558466 | — | — | 1 | 6.93 |
| CHEMBL5548822 | — | — | 1 | 6.88 |
| CHEMBL3582252 | — | — | 1 | 6.80 |
| CHEMBL5557114 | — | — | 1 | 6.64 |
| CHEMBL5559186 | — | — | 1 | 6.64 |
| CHEMBL5558785 | — | — | 1 | 6.60 |
| CHEMBL5517664 | — | — | 1 | 6.58 |
| CHEMBL5532018 | — | — | 1 | 6.57 |
| CHEMBL5557741 | — | — | 1 | 6.52 |
| CHEMBL5505830 | — | — | 1 | 6.45 |
| CHEMBL5558701 | — | — | 1 | 6.42 |
| CHEMBL5527933 | — | — | 1 | 6.30 |
| CHEMBL5517954 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5527862 | — | IC50 | = | 1.21 | nM | 8.92 |
| CHEMBL5542281 | — | IC50 | = | 1.98 | nM | 8.70 |
| CHEMBL5555050 | — | IC50 | = | 2.25 | nM | 8.65 |
| CHEMBL5505768 | — | IC50 | = | 2.62 | nM | 8.58 |
| CHEMBL5523436 | — | IC50 | = | 13.18 | nM | 7.88 |
| CHEMBL5517848 | — | IC50 | = | 17.54 | nM | 7.76 |
| CHEMBL5532170 | — | IC50 | = | 24.02 | nM | 7.62 |
| CHEMBL5555775 | — | IC50 | = | 25.56 | nM | 7.59 |
| CHEMBL5505855 | — | IC50 | = | 27.12 | nM | 7.57 |
| CHEMBL5518088 | — | IC50 | = | 27.31 | nM | 7.56 |
| CHEMBL5517955 | — | IC50 | = | 39.53 | nM | 7.40 |
| CHEMBL5555127 | — | IC50 | = | 55.1 | nM | 7.26 |
| CHEMBL5532067 | — | IC50 | = | 64.33 | nM | 7.19 |
| CHEMBL5555650 | — | IC50 | = | 72.42 | nM | 7.14 |
| CHEMBL5527981 | — | IC50 | = | 78.6 | nM | 7.11 |
| CHEMBL5557259 | — | IC50 | = | 108.7 | nM | 6.96 |
| CHEMBL5512521 | — | IC50 | = | 113.23 | nM | 6.95 |
| CHEMBL5558466 | — | IC50 | = | 118.12 | nM | 6.93 |
| CHEMBL5548822 | — | IC50 | = | 133.17 | nM | 6.88 |
| CHEMBL3582252 | — | IC50 | = | 158.3 | nM | 6.80 |
| CHEMBL5557114 | — | IC50 | = | 227.56 | nM | 6.64 |
| CHEMBL5559186 | — | IC50 | = | 231.42 | nM | 6.64 |
| CHEMBL5558785 | — | IC50 | = | 253.62 | nM | 6.60 |
| CHEMBL5517664 | — | IC50 | = | 262.74 | nM | 6.58 |
| CHEMBL5532018 | — | IC50 | = | 271.34 | nM | 6.57 |
| CHEMBL5557741 | — | IC50 | = | 302.13 | nM | 6.52 |
| CHEMBL5505830 | — | IC50 | = | 358.15 | nM | 6.45 |
| CHEMBL5558701 | — | IC50 | = | 381.03 | nM | 6.42 |
| CHEMBL5527933 | — | IC50 | = | 505.89 | nM | 6.30 |
| CHEMBL5517954 | — | IC50 | = | 893.38 | nM | 6.05 |
| CHEMBL5558044 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5558515 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5558479 | — | IC50 | > | 1000.0 | nM | - |