Assay Detail
Functional
CHEMBL5502149
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Cytotoxicity against human HCT-116 cells assessed as inhibition of cell viability incubated for 72 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Improving tumor sensitivity by the introduction of an ester chain to triaryl derivatives targeting PD-1/PD-L1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.98 | 5.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5523436 | — | — | 1 | 5.13 |
| CHEMBL5505855 | — | — | 1 | 4.91 |
| CHEMBL5542281 | — | — | 1 | 4.91 |
| CHEMBL5518088 | — | — | 1 | - |
| CHEMBL5517848 | — | — | 1 | - |
| CHEMBL5505768 | — | — | 1 | - |
| CHEMBL5555050 | — | — | 1 | - |
| CHEMBL5527862 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5523436 | — | IC50 | = | 7350.0 | nM | 5.13 |
| CHEMBL5505855 | — | IC50 | = | 12240.0 | nM | 4.91 |
| CHEMBL5542281 | — | IC50 | = | 12180.0 | nM | 4.91 |
| CHEMBL5518088 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5517848 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5505768 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5555050 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5527862 | — | IC50 | > | 20000.0 | nM | - |