Assay Detail
Binding
CHEMBL5502247
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BRD4 BD1 (unknown origin) incubated for 120 mins by TR-FRET assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of potent and novel dual NAMPT/BRD4 inhibitors for efficient treatment of hepatocellular carcinoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.72 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5556421 | — | — | 1 | 7.92 |
| CHEMBL1957266 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5556421 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1957266 | — | IC50 | = | 30.0 | nM | 7.52 |