Assay Detail

CHEMBL5503034

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Functional

Inhibition of FcgammaR-mediated ROS production in neutrophils (unknown origin)

ChEMBL ↗

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Target

Neutrophil (CHEMBL613710) ↗

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Primary target Neutrophil

CHEMBL613710

Anchored from Assay target.

Protein identity Neutrophil

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Not specified
Cell Type	Neutrophil
Confidence	1 — Organism
Curated By	Autocuration

Target

Neutrophil (CHEMBL613710) ↗

Type

CELL-LINE

Publication

Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis.

Himmelbauer MK, Bajrami B, Basile R, Capacci A, Chen T, Choi CK, Gilfillan R, Gonzalez-Lopez de Turiso F, Gu C, Hoemberger M, Johnson DS, Jones JH, Kadakia E, Kirkland M, Lin EY, Liu Y, Ma B, Magee T, Mantena S, Marx IE, Metrick CM, Mingueneau M, Murugan P, Muste CA, Nadella P, Nevalainen M, Parker Harp CR, Pattaropong V, Pietrasiewicz A, Prince RJ, Purgett TJ, Santoro JC, Schulz J, Sciabola S, Tang H, Vandeveer HG, Wang T, Yousaf Z, Helal CJ, Hopkins BT.
J Med Chem (2024) 67 : 8122 -8140
PubMed 38712838 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.49	8.49

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL5532458	—	—	1	8.49

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL5532458	—	IC50	=	3.2	nM	8.49