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Assay Detail

CHEMBL5503164

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of VEGFR2 (unknown origin)
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Vascular endothelial growth factor receptor 2 (CHEMBL279)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Recent advances and future directions on small molecule VEGFR inhibitors in oncological conditions.
Thakur A, Rana M, Mishra A, Kaur C, Pan CH, Nepali K.
Eur J Med Chem (2024) 272 : 116472 -116472
PubMed 38728867 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 6.77 8.32

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5549937 1 8.32
CHEMBL5418423 1 8.15
CHEMBL5517643 1 7.80
CHEMBL5556008 1 7.60
CHEMBL5542272 1 7.50
CHEMBL5518141 1 7.31
CHEMBL1336 SORAFENIB 4.0 1 7.24
CHEMBL5505791 1 7.17
CHEMBL5559400 1 7.16
CHEMBL24828 VANDETANIB 4.0 1 7.03
CHEMBL5512476 1 7.01
CHEMBL5557132 1 6.96
CHEMBL5558244 1 6.64
CHEMBL5427272 1 5.96
CHEMBL5532112 1 5.91
CHEMBL5437292 1 5.44
CHEMBL5517680 1 5.23
CHEMBL5403883 1 5.09
CHEMBL5557202 1 5.03
CHEMBL5557998 1 -
CHEMBL5558572 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5549937 IC50 = 4.8 nM 8.32
CHEMBL5418423 IC50 = 7.0 nM 8.15
CHEMBL5517643 IC50 = 16.0 nM 7.80
CHEMBL5556008 IC50 = 25.0 nM 7.60
CHEMBL5542272 IC50 = 32.0 nM 7.50
CHEMBL5518141 IC50 = 49.0 nM 7.31
CHEMBL1336 SORAFENIB IC50 = 58.0 nM 7.24
CHEMBL5505791 IC50 = 67.0 nM 7.17
CHEMBL5559400 IC50 = 70.0 nM 7.16
CHEMBL24828 VANDETANIB IC50 = 94.0 nM 7.03
CHEMBL5512476 IC50 = 98.0 nM 7.01
CHEMBL5557132 IC50 = 111.0 nM 6.96
CHEMBL5558244 IC50 = 230.11 nM 6.64
CHEMBL5427272 IC50 = 1090.0 nM 5.96
CHEMBL5532112 IC50 = 1230.0 nM 5.91
CHEMBL5437292 IC50 = 3620.0 nM 5.44
CHEMBL5517680 IC50 = 5873.0 nM 5.23
CHEMBL5403883 IC50 = 8200.0 nM 5.09
CHEMBL5557202 IC50 = 9400.0 nM 5.03
CHEMBL5557998 IC50 = 19780.0 nM -
CHEMBL5558572 IC50 = 25140.0 nM -