Assay Detail
Binding
CHEMBL5503407
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to wild type FKBP51 (unknown origin) assessed as inhibition constant by fluorescence polarization assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peptidyl-prolyl cis-trans isomerase FKBP5 (CHEMBL2052031) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Macrocyclization strategy for improving candidate profiles in medicinal chemistry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 8.31 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3623612 | — | — | 1 | 8.40 |
| CHEMBL3623630 | — | — | 1 | 8.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3623612 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL3623630 | — | Ki | = | 6.0 | nM | 8.22 |