Assay Detail
Binding
CHEMBL5503853
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Sirt2 deacetylation preincubated for 15 mins followed by H3K9-Ac substrate addition
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacetylase sirtuin-2 (CHEMBL4462) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-Activity Studies of 1,2,4-Oxadiazoles for the Inhibition of the NAD<sup>+</sup>-Dependent Lysine Deacylase Sirtuin 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.46 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5556672 | — | — | 1 | 7.52 |
| CHEMBL4129995 | — | — | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5556672 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4129995 | — | IC50 | = | 40.0 | nM | 7.40 |