Assay Detail
Functional
CHEMBL5503901
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of carbachol-induced smooth muscle contraction in male albino Dunkin-Hartley guinea pig trachea
19
Total Activities
18
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Trachea |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery, Multiparametric Optimization, and Solid-State Driven Identification of CHF-6550, a Novel Soft Dual Pharmacology Muscarinic Antagonist and β<sub>2</sub> Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 9.55 | 10.70 |
| pIC50 | 6 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5555744 | — | — | 1 | 10.70 |
| CHEMBL5505816 | — | — | 2 | 10.30 |
| CHEMBL5532029 | — | — | 1 | 9.90 |
| CHEMBL5558368 | — | — | 1 | 9.90 |
| CHEMBL5550055 | — | — | 1 | 9.80 |
| CHEMBL6067687 | — | — | 1 | 9.60 |
| CHEMBL5172865 | — | — | 1 | 9.50 |
| CHEMBL5555665 | — | — | 1 | 9.30 |
| CHEMBL5527960 | — | — | 1 | 9.30 |
| CHEMBL5517637 | — | — | 1 | 9.10 |
| CHEMBL5505925 | — | — | 1 | 9.00 |
| CHEMBL5542735 | — | — | 1 | 9.00 |
| CHEMBL5512435 | — | — | 1 | 8.80 |
| CHEMBL5523458 | — | — | 1 | - |
| CHEMBL5556153 | — | — | 1 | - |
| CHEMBL5523340 | — | — | 1 | - |
| CHEMBL5542602 | — | — | 1 | - |
| CHEMBL5556756 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5555744 | — | IC50 | = | 0.01995 | nM | 10.70 |
| CHEMBL5505816 | — | IC50 | = | 0.05012 | nM | 10.30 |
| CHEMBL5532029 | — | IC50 | = | 0.1259 | nM | 9.90 |
| CHEMBL5558368 | — | IC50 | = | 0.1259 | nM | 9.90 |
| CHEMBL5550055 | — | IC50 | = | 0.1585 | nM | 9.80 |
| CHEMBL6067687 | — | IC50 | = | 0.2512 | nM | 9.60 |
| CHEMBL5172865 | — | IC50 | = | 0.3162 | nM | 9.50 |
| CHEMBL5555665 | — | IC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL5527960 | — | IC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL5517637 | — | IC50 | = | 0.7943 | nM | 9.10 |
| CHEMBL5505925 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5542735 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5512435 | — | IC50 | = | 1.585 | nM | 8.80 |
| CHEMBL5523458 | — | pIC50 | - | — | - | |
| CHEMBL5556153 | — | pIC50 | - | — | - | |
| CHEMBL5505816 | — | pIC50 | - | — | - | |
| CHEMBL5523340 | — | pIC50 | - | — | - | |
| CHEMBL5542602 | — | pIC50 | - | — | - | |
| CHEMBL5556756 | — | pIC50 | - | — | - |