Assay Detail
Binding
CHEMBL5504538
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Binding affinity to human alpha2A-adrenoceptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Designing Chromane Derivatives as α<sub>2A</sub>-Adrenoceptor Selective Agonists via Conformation Constraint.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.11 | 9.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5517941 | — | — | 1 | 9.50 |
| CHEMBL5523596 | — | — | 1 | 8.08 |
| CHEMBL4594267 | TASIPIMIDINE | 2.0 | 1 | 8.06 |
| CHEMBL5517987 | — | — | 1 | 7.92 |
| CHEMBL5542211 | — | — | 1 | 7.81 |
| CHEMBL5542553 | — | — | 1 | 7.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5517941 | — | Ki | = | 0.3162 | nM | 9.50 |
| CHEMBL5523596 | — | Ki | = | 8.318 | nM | 8.08 |
| CHEMBL4594267 | TASIPIMIDINE | Ki | = | 8.71 | nM | 8.06 |
| CHEMBL5517987 | — | Ki | = | 12.02 | nM | 7.92 |
| CHEMBL5542211 | — | Ki | = | 15.49 | nM | 7.81 |
| CHEMBL5542553 | — | Ki | = | 51.29 | nM | 7.29 |