Compound Detail
CHEMBL4594267
TASIPIMIDINE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL4594267 |
| Name | TASIPIMIDINE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | GHIKYGQWBRHEGU-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
6
Publications
4
Known Names
2
Indications
Molecular Properties
232.3
MW (Da)
1.31
ALogP
4
HBA
1
HBD
42.9
PSA (Ų)
0.84
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Racemic |
Indications
Analgesia Anxiety Disorders
Activity Summary
Ki 4 meas. best 8.06
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Alpha-2A adrenergic receptor CHEMBL1867 | Ki | 8.06 | 8.06 | 8.7 | 1 |
| Alpha-1B adrenergic receptor CHEMBL232 | Ki | 6.28 | 6.28 | 524.8 | 1 |
| Alpha-1D adrenergic receptor CHEMBL223 | Ki | 5.51 | 5.51 | 3090.3 | 1 |
| Alpha-1A adrenergic receptor CHEMBL229 | Ki | 5.51 | 5.51 | 3090.3 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Alpha-2A adrenergic receptor | Ki | = | 8.71 | nM | 8.06 | Binding affinity to human alpha2A-adrenoceptor | 38889119 |
| Alpha-1B adrenergic receptor | Ki | = | 524.81 | nM | 6.28 | Binding affinity to human alpha1B-adrenoceptor | 38889119 |
| Alpha-1A adrenergic receptor | Ki | = | 3090.3 | nM | 5.51 | Binding affinity to human alpha1A-adrenoceptor | 38889119 |
| Alpha-1D adrenergic receptor | Ki | = | 3090.3 | nM | 5.51 | Binding affinity to human alpha1D-adrenoceptor | 38889119 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38889119 | 10.1021/acs.jmedchem.4c01239 | Alpha-2A adrenergic receptor | 1 |
| 38889119 | 10.1021/acs.jmedchem.4c01239 | Alpha-2B adrenergic receptor | 1 |
| 38889119 | 10.1021/acs.jmedchem.4c01239 | Alpha-2C adrenergic receptor | 1 |
| 38889119 | 10.1021/acs.jmedchem.4c01239 | Alpha-1A adrenergic receptor | 1 |
| 38889119 | 10.1021/acs.jmedchem.4c01239 | Alpha-1B adrenergic receptor | 1 |
| 38889119 | 10.1021/acs.jmedchem.4c01239 | Alpha-1D adrenergic receptor | 1 |
Data from ChEMBL 36 via Core Engine