Assay Detail
Binding
CHEMBL5504542
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Binding affinity to human alpha1B-adrenoceptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Designing Chromane Derivatives as α<sub>2A</sub>-Adrenoceptor Selective Agonists via Conformation Constraint.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.04 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5517941 | — | — | 1 | 7.70 |
| CHEMBL4594267 | TASIPIMIDINE | 2.0 | 1 | 6.28 |
| CHEMBL134 | CLONIDINE | 4.0 | 1 | 5.13 |
| CHEMBL778 | DEXMEDETOMIDINE | 4.0 | 1 | 5.04 |
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | - |
| CHEMBL862 | GUANFACINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5517941 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL4594267 | TASIPIMIDINE | Ki | = | 524.81 | nM | 6.28 |
| CHEMBL134 | CLONIDINE | Ki | = | 7413.1 | nM | 5.13 |
| CHEMBL778 | DEXMEDETOMIDINE | Ki | = | 9120.11 | nM | 5.04 |
| CHEMBL1437 | NOREPINEPHRINE | Ki | = | 162181.01 | nM | - |
| CHEMBL862 | GUANFACINE | Ki | = | 134896.29 | nM | - |