Assay Detail
Functional
CHEMBL5504551
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at alpha2C-adrenoceptor (unknown origin) expressed in CHO-alpha2C-PKAcatEGFP cells assessed as increase in intracellular calcium level measured after 15 mins incubation by Micro automated microscopy
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Designing Chromane Derivatives as α<sub>2A</sub>-Adrenoceptor Selective Agonists via Conformation Constraint.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.61 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL778 | DEXMEDETOMIDINE | 4.0 | 1 | 8.27 |
| CHEMBL5532450 | — | — | 1 | 7.67 |
| CHEMBL5512438 | — | — | 1 | 7.55 |
| CHEMBL5557226 | — | — | 1 | 7.45 |
| CHEMBL5558235 | — | — | 1 | 7.43 |
| CHEMBL5558705 | — | — | 1 | 7.30 |
| CHEMBL5558506 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL778 | DEXMEDETOMIDINE | EC50 | = | 5.37 | nM | 8.27 |
| CHEMBL5532450 | — | EC50 | = | 21.3 | nM | 7.67 |
| CHEMBL5512438 | — | EC50 | = | 27.9 | nM | 7.55 |
| CHEMBL5557226 | — | EC50 | = | 35.8 | nM | 7.45 |
| CHEMBL5558235 | — | EC50 | = | 37.2 | nM | 7.43 |
| CHEMBL5558705 | — | EC50 | = | 49.6 | nM | 7.30 |
| CHEMBL5558506 | — | EC50 | > | 5000.0 | nM | - |